Martin F. Bachmann,Tazio Storni,Patrik Maurer,Alain Tissot,Katrin Schwarz,Edwin Meijerink,Gerd Lipowsky,Paul Pumpens,Indulis Cielens,Regina Renhofa
申请号：
US13294006
公开号：
US08691209B2
申请日:
2011.11.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G (CpGs). Such CpG-VLPs are dramatically more immunogenic than their CpG-free counterparts and induce enhanced B and T cell responses. The immune response against antigens optionally coupled, fused or attached otherwise to the VLPs is similarly enhanced as the immune response against the VLP itself. In addition, the T cell responses against both the VLPs and antigens are especially directed to the Th1 type. Antigens attached to CpG-loaded VLPs may therefore be ideal vaccines for prophylactic or therapeutic vaccination against allergies, tumors and other self-molecules and chronic viral diseases.
