Agency for Science, Technology and Research;Lion TCR
发明人:
Guccione, Ernest,Wee, Keng Boon Dave,Bertoletti, Antonio
申请号：
AU2018291556
公开号：
AU2018291556A1
申请日:
2018.06.27
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates to antisense oligonucleotides for modulating the function of a T cell, including antisense oligonucleotides that hybridise to IFN-γ, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed is a method for further modifying the specificity of said T-cell by providing for a T cell receptor gene.
