Disclose a kind of device, system and method, it is used for installing for example signal of pick off with for example being transported to mammalian skin such as pick off or fluid delivery structure or the such device of fluid delivery structure sensor combinations and receiving, analyze and show from this.Comprise according to the system of the embodiment of the invention have emitter, the re-used sensor cluster of microcontroller and shell and have shell and the disposable sensor assembly of transmitting device, the shell of described disposable sensor assembly has and is used to receive the opening that biosensor, pick off insert the far-end of guide frame, and the signal that described transmitting device is used for receiving from pick off is transferred to and can re-uses sensor cluster to be used to be transferred to the external electrical monitor unit.