Soldano Ferrone,Xinhui Wang,Thomas P. Conrads,Elvira Favoino,Brian L. Hood
申请号：
US13161432
公开号：
US20120009194A1
申请日:
2011.06.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.
