The present invention relates to a vaginal speculum embodying an applicator for the uniform delivery of a standardized dose of a liquid diagnostic marker onto the womans lower genital tract. The applicator comprises of a marker container and a mechanism for transferring a desirable quantity of its content to an injection probe for dispensing the marker onto the tissue surface. The probe may be a nozzle generating a desirable injection pattern, depending on the location of the tissues to be examined. The probe may be affixed to an extension rod, which may be mechanically coupled with the speculum blades. Optical, electronic imaging means, illumination means and treatment tools may be mounted onto the extension rod, which rod may be detachably attached to mechanical positioning systems or to imaging devices used in colposcopy. The disclosed speculum arrangement may be used as a tool for diagnostic and screening examinations and for the treatment of cervical and vaginal neoplasias.