Method for screening microtubule elongation inhibitor and microtubule elongation inhibitor

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专利权人:

独立行政法人国立循環器病研究センター

发明人:

北風 政史,望月 直樹,高島 成二,中野 敦

申请号：

JP2009160508

公开号：

JP5578464B2

申请日:

2009.07.07

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a method of screening a microtubule growth inhibitor according to a novel mechanism, and a novel microtubule growth inhibitor.SOLUTION: There are disclosed a method of screening a substance that inhibits the phosphorylation of CLIP-170 by AMPK, wherein the phosphorylation of CLIP-170 by AMPK is employed as an indicator； a method of screening a microtubule growth inhibitor, wherein the phosphorylation of CLIP-170 by AMPK is employed as an indicator； a microtubule growth inhibitor including, as an effective component, the substance that inhibits the phosphorylation of CLIP-170 by AMPK； and a polypeptide of varied-type CLIP-170 wherein an amino acid of CLIP-170 phosphorylatated by AMPK is varied.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/