Gema Panizo Del Pliego;Miguel Medina Padilla;Mercedes Alonso Cascon;Maria Jose Perez Puerto;Ana Fuertes Huerta;Ana Martinez Gil;Isabel Dorronsoro Diaz
发明人:
Miguel Medina Padilla,Mercedes Alonso Cascon,Isabel Dorronsoro Diaz,Ana Martinez Gil,Gema Panizo Del Pliego,Ana Fuertes Huerta,Maria Jose Perez Puerto
申请号：
US12428442
公开号：
US08158661B2
申请日:
2009.04.22
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided are thiadiazolidine compounds of formula Iwherein R1 is an organic group having at least 8 atoms selected from C or O, which is not linked directly to the N through a —C(O)— and comprising at least an aromatic ring, and their pharmaceutical compositions. These compounds are selective GSK-3 inhibitors and have improved bioavailability. They are useful for the treatment of GSK-3 mediated diseases, among others Alzheimer's disease, type II diabetes, depression and brain injury.
