Fluid removal systems and methods for removing fluid from a tissue site arepresented. The system includes asemi-permeable inbound conduit (106), which is fluidly coupled to a treatment-fluid delivery unit (104), for placement proximateto a tissue site (102), and a semi-permeable outbound conduit (108), which isfluidly coupled to the inbound conduit (106) and toa treatment-fluid collector (114), for placement proximate to the tissue site(102) on the patient. The treatment-fluid collector(114) receives the treatment fluid and a recruited fluid from the tissue site(102). A recruited- fluid determination unit (122) maybe coupled to the treatment-fluid collector (114) to determine a volume offluid recruited from the patient. The treatment fluid isany fluid (including a gas) that pulls fluid from the interstitial andintracellular space. A reduced-pressure treatment subsystemmay also be included, among other things, for removing ascites and otherfluids from a body cavity.