There is disclosed an endotracheal device for mechanical ventilation suitable to be partly positioned inside the trachea (T) of a patient, and comprising a ventilation tube (2) including at least a proximal port (2a), suitable to be constrained to a machine for mechanical ventilation, and at least a distal port (2b) in fluid communication with the proximal port (2a), an inflatable and deflatable primary cuff (4) suitable to allow sealing or insertion of the device (1) inside the trachea, and also comprising irrigation means (8) of the trachea suitable to allow irrigation in proximity of said primary cuff (4).