MCPHERSON, JOHN M.,EDMUNDS, TIM,ZHOU, QUN,MCPHERSON JOHN M.,EDMUNDS TIM,ZHOU QUN
申请号：
PL06846120
公开号：
PL1945665T3
申请日:
2006.10.20
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.
