A leadless wireless ECG measurement system for measuring of bio-potentials includes at least one multi-contact bio-potential electrode assembly adapted for attachment to the patient's body to measure ECG. A processing unit is configured to produce a transfer function which computes estimated long-lead ECG signals based on the measured short-lead ECG signals from the plurality of contact points. This invention describes calibration process of short-lead ECG with standard lead ECG without requiring use of lead wires, only using a flexibly moving body part (finger) to calibrate patch. The invention describes use of algorithms for biopotential signal separation from mixed sources. The invention describes use of signal separation for identification of abnormal signals and the localization of biopotential source tissue. This invention describes effective biopotential evoked potential stimulation. The invention also describes biopotential neutralization of undesired biopotential.
