Eric M. BRESSLER,Jordan J. GREEN,Niranjan B. PANDEY,Aleksander S. POPEL,Ron B. SHMUELI, Sr.
申请号:
US15776971
公开号:
US20180339024A1
申请日:
2016.11.18
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention in various aspects and embodiments involves pharmaceutical compositions of peptides derived from the α5 fibril of type IV collagen, and uses thereof for medical treatment. The peptides target α5β1 and αVβ3 integrins, and inhibit signaling through multiple receptors, and find use for inhibiting vascular permeability, angiogenesis, lymphangiogenesis.