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Crystalline salts of acid amide (4S, 4aS, 5aR, 12aS) -4-dimethylamino-3,10,12,12a-tetrahydroxy-7 - [(methoxy (methyl) amino) -methyl] -1,11-dioxo- 1,4,4a, 5,5a, 6,11,12a-octahydro-naphthacen-2-carboxylic and methods of use thereof
专利权人:
Paratek Pharmaceuticals, Inc.;Allergan Pharmaceuticals International Limited
发明人:
COULTER, Catherine,JOHNSTON, Sean M.,SEYEDI, Farzaneh
申请号:
ES12782600
公开号:
ES2739626T3
申请日:
2012.05.14
申请国别(地区):
ES
年份:
2020
代理人:
摘要:
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino- 3,10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4S,4aS,5aR,12aS)-4-dimethyl-amino-3,10,12,12a-tetrahydroxy-7- [(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene- 2-carboxylic acid amide are also disclosed having improved stability. A pharmaceutical composition containing the crystalline salts and methods of treating inflammatory skin disorders and bacterial infections comprising administering the crystalline salts are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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