BUTTERWORTH, SAM,FINLAY, MAURICE RAYMOND VERSCHOYLE,WARD, RICHARD ANDREW,KADAMBAR, VASANTHA KRISHNA,CHANDRASEKHARA, REDDY CHINTAKUNTLA,MURUGAN, ANDIAPPAN,REDFEARN, HEATHER MARIE,CHUAQUI, CLAUDIO EDMUN
申请号：
PE0025322013
公开号：
PE17002014A1
申请日:
2012.07.25
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a compound of formula I or a pharmaceutically acceptable Salt thereof, where: G is selected tetrahidropirazolo 4,5,6,7 - [1,5-a] pyridin - 3 - ILO, ILO 1h indole - 3 - 1 - methyl - 1H indole - 3 - ILO and pyrazolo [1,5-a] pyridin - 3 - ilo r1 is H, Fluorine, Chlorine, Methyl and methoxy and methyl cyano R2 and R3 is Is (3R) - 3 - (dimethylamino) - pyrrolidin-3-yl 1 - ILO, (3S) - 3 - (dimethyl amino) - pyrrolidin-3-yl 1 - ilo3 - (dimethylamino) - 1 - azetidin ILO, among others. Preferred compounds are: N - (4 - methoxy - 2 - [1 - methyl - 3.6 - dihydro - 2H - pyridin-4-yl] - 5 - [(2 - methyl - 4 - pyrazolo [1,5-a] pyridin - 3 - ilpirimidin IL - 2 - phenyl) amino] - 2} prop - enamida n - (5 - [4 - (5 - Chloro - 1H indole - 3 - il il pyrimidin-2-yl) - 2 - amino - 4 - methoxy}] - 2 - [1 - methyl - 3.6 - dihydro - 2H - pyridin-4-yl] phenyl) - 2 - enamida prop among others. It also relates to a Pharmaceutical composition.This Compound is an inhibitor of mutated forms of EGFR (epidermal growth factor receptor). Useful in the treatment of cancer.SE REFIERE A UN COMPUESTO DE FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE: G SE SELECCIONA DE 4,5,6,7-TETRAHIDROPIRAZOLO[1,5-A]PIRIDIN-3-ILO, 1H-INDOL-3-ILO, 1-METIL-1H-INDOL-3-ILO Y PIRAZOLO[1,5-A]PIRIDIN-3-ILO R1 ES H, FLUOR, CLORO, METILO Y CIANO R2 ES METOXI Y METILO Y R3 ES (3R)-3-(DIMETILAMINO)PIRROLIDIN-1-ILO, (3S)-3-(DIMETIL-AMINO)PIRROLIDIN-1-ILO, 3-(DIMETILAMINO)AZETIDIN-1-ILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-{4-METOXI-2-[1-METIL-3,6-DIHIDRO-2H-PIRIDIN-4-IL]-5-[(5-METIL-4-PIRAZOLO[1,5-A]PIRIDIN-3-ILPIRIMIDIN-2-IL)AMINO]FENIL}PROP-2-ENAMIDA N-(5-{[5-CLORO-4-(1H-INDOL-3-IL)PIRIMIDIN-2-IL]AMINO}-4-METOXI-2-[1-METIL-3,6-DIHIDRO-2H-PIRIDIN-4-IL]FENIL)PROP-2-ENAMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UN INHIBIDOR DE LAS FORMAS MUTADAS DEL EGFR (RECEPTOR DEL FACTOR DE CRECIMIENTO EPIDERMICO). UTIL EN EL TRATAMIENTO DEL CANCER.
