Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis

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专利权人:

NORTHWEST BIOTHERAPEUTICS; INC.

发明人:

MURPHY, GERALD P.,BOYNTON, ALTON L.,SEHGAL, ANIL

申请号：

ES99916365

公开号：

ES2156581T5

申请日:

1999.03.29

申请国别(地区):

ES

年份:

2015

代理人:

摘要：

The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXC R- 4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.

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中国工程科技知识中心

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http://www.ckcest.cn/home/