CHEN, Wei,WANG, Longcheng,JIA, Zhaozhong, J.,PALMER, James, T.
申请号：
USUS2015/043102
公开号：
WO2016/019237A3
申请日:
2015.07.31
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
Described herein are cyano containing bicyciic heteroaryl compounds that are irreversible inhibitors of Brutons tyrosine kinase (BTK) activity and pharmaceutical compositions containing the same for the teatment of BTK mediated disorders in a subject. Methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases such as cancer, mastocytosis, B-cell lymphoma, lupus and osteoporosis are also described.Linvention concerne des composés hétéroaryle contenant un groupe cyano qui sont utiles en tant quinhibiteurs des kinases. Linvention concerne également des procédés de synthèse de tels inhibiteurs et des méthodes dutilisation de ces inhibiteurs dans le traitement de maladies.
