YUN WU,Dennis J. KOPECKO,B. Kim Lee SIM,Stephen L. HOFFMAN
申请号：
US15742459
公开号：
US20180264099A1
申请日:
2016.07.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Disclosed is the attenuated Salmonella typhi vaccine Ty21a utilized as a vector for Shigella and/or enterotoxogenic E. coli genes stably integrated in the Ty21a chromosome. These genes include a heterologous Shigella sonnei O-antigen biosynthetic gene region that comprises the wzz gene and expresses Shigella sonnei form 1 O-antigen, as well as a heterologous acid resistance biosynthetic gene system comprising a YbaS gene, which enables increased stability of the Ty21a vector at pH 2.5 relative to Ty21a without the integrated acid resistance biosynthetic gene system.
