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COMPOSITIONS OF SKIN FILLERS
专利权人:
ИНК. (US);АЛЛЕРГАН
发明人:
НЦЗИКАН Гэбриел Н. (US),ЮЙ Сяоцзе (US),ЛЮ Футянь (US),МАНЕЗИС Николас Джей (US)
申请号:
RU2014127607
公开号:
RU2014127607A
申请日:
2012.12.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A method of producing an injectable skin filler composition for treating skin wrinkles, comprising the steps of crosslinking hyaluronic acid (HA) with a diamine or polyamine crosslinker in the presence of a carbodiimide binding agent. The method according to claim 1, characterized in that the crosslinker is a linear diamine crosslinker. A method according to claim 2, characterized in that the crosslinker is hexamethylenediamine (HMDA). The method according to claim 1, wherein the crosslinker is 3- [3- (3-amino-propoxy) -2,2-bis (3-amino-propoxymethyl) propoxy] propylamine (4 AA). 5. A method according to claim 1, characterized in that the crosslinker consists of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains originating from a central point. A method according to claim 1, characterized in that the crosslinker consists of at least three polyethylene glycol (PEG) chains and no more than eight PEG chains starting from a central point, with each chain having an amino end group. A method according to claim 1, characterized in that the crosslinker contains polyethylene glycol (PEG) chains having at least one ethylene glycol unit and not more than 55 ethylene glycol units. A method according to claim 1, characterized in that the crosslinker is a lysine methyl ester. The method of claim 1, wherein the binding agent is 1-ethyl-3- [3-dimethylaminopropyl] carbodiimide hydrochloride (EDC). 10. A method according to claim 1, characterized in that the crosslinking occurs in the presence of 1-ethyl-3- [3-dimethylaminopropyl] carbodiimide hydrochloride (EDC). 11. The method of claim 10, wherein the crosslinking occurs in the presence of N-hydroxysuccinimide (NHS) or N-hydroxysulfosuccinimide (sulfoNHS). The composition of the cutaneous1. Способ получения инъецируемой композиции кожного наполнителя для лечения морщин на коже, включающий стадии поперечного сшивания гиалуроновой кислоты (ГК) с диаминным или полиаминным сшивателем в присутствии кар
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