KU, TIEN HSIUNG,古天雄,古天雄,HSU, FANG RONG,许芳荣,許芳榮,SHIA, WEI CHUNG,夏伟中,夏偉中,TSAO, YU MING,曹育铭,曹育銘,TANG, CHUAN YI,唐传义,唐傳義
申请号：
TW101101540
公开号：
TW201331361A
申请日:
2012.01.16
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
This invention relates to an analysis of copy number variants (CNVs) in genomic DNA samples of patients. This invention uses a single nucleotide polymorphism array (SNP array) analysis and the real-time polymerase chain reaction (real-time PCR) to detect the regions with genetic copy number variants, so as to determine whether the copy number variant regions (CNVRs) of the samples are associated with the hyperlipidemia and myocardial infarction, providing as the biomarker for early diagnosis of the hyperlipidemia and myocardial infarction.本發明係利用分析病人基因組DNA樣品(genomic DNA)的拷貝數變異(copy number variants,CNV),本研究係使用單核苷酸多型性生物晶片(single nucleotide polymorphism array,簡稱SNP array)分析及即時聚合酶連鎖反應(Real-time PCR)檢測基因複製數變異的區域,以偵測樣品的拷貝數變異區域(CNVRs)是否與高脂血症和心肌梗塞有關,來作為高脂血症和心肌梗塞的早期診斷生物標記(biomarker)。
