KREMOSER, CLAUS,DEUSCHLE, ULRICH,HAMBRUCH, EVA,BIRKEL, MANFRED,GEGE, CHRISTIAN
申请号：
ARP180101928
公开号：
AR112272A1
申请日:
2018.07.11
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Claim 1: compound (1) represented by formula,A dwarf isomer, symmetric isomer, tautometer, N-oxide, solution, production and pharmaceutically acceptable salt, where R1,R2. Select from H and c833213183832424 - tar independently, among which one or three substitutes selected independently from halogen are not enough to use or replace tar, CN, oh, oxo, c83321218c833224 - tar, halo-c83321833183832424231 - tar, o-c833212183383383383383 - tar, o-c833183248383 - coke oil and o-halo-c183218338388383-2383； O r 1 and R 2 together are a 3-6 member toroidal arc, or a 3-6 member non toroidal arc, which is composed of 1-4 atoms independently selected from n or s, in which the toroidal arc and non toroidal arc are not interfered, or replaced by 1-4 substitutes independently selected from halogen, CN, Oh, oxo, c8327c8333183247akilo,A. halo-c833218331c833c83248c8333183248c833248c833248akilo, o-halo-cc27183318383248c83324akilo； or R1 and the residue adjacent to ring C form 5 to 8 saturated or partially unsaturated chemical rings, or 5 to 8 non chemical rings； A. saturated or partially unsaturated, containing 1 to 4 heteroatoms independently selected from n, O and s, wherein cyclopropene or isopropenylpropylene is not adsorbed or replaced by 1 to 4 substitutes independently selected from halogen, CN, oh, cc28331838331832483383242424 tar, halo-c83183248332183 tar； O-c83218331-asphalt and o-halo-c832183-832424-asphalt； R3,E. r830808 is independently selected from H and c83231832483248324833248324 tar. Among them, asphalt has one or three independently selected alternatives from halogen: CN, oh, oxo, c83321833183328324 tar, halo-c833218331833283224 tar, o-c83321833183318324 tar and o-halo-c2183318383-248383； O r 3 and r83088 together are 3-6 members of cyclopentadiol o r 3-6 members of non cyclopentadiol, which contains 1-4 heteroatoms independently selected from n or s, cyclopentadiol and isocyclopentadiene dibenzene are not imported or replaced by 1-4 independently selected substitutes
