WELCH, DENNIE S.,AKRITOPOULOU-ZANZE, IRINI,BRAJE, WILFRIED,DJURIC, STEVAN W.,WILSON, NOEL S.,TURNER, SEAN C.,KRUGER, ALBERT W.,RELO, ANA-LUCIA,SHEKHAR, SHASHANK,ZHAO, HONGYU,GANDARILLA, JORGE,GASIECKI
申请号：
ES10720502
公开号：
ES2423668T3
申请日:
2010.05.20
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A compound of formula (I): Formula ** ** or a pharmaceutically acceptable thereof, wherein A is selected from the group consisting of R1, R3, R4 salt, and R5 are independently selected from the group consisting of hydrogen, alkenyl, alkyl, haloalkyl, G1, G2, - (CR4aR5a) m-G1 and - (CR4aR5a) m-G2 R4a and R5a, at each occurrence, are each independently hydrogen, halogen, alkyl, or haloalkyl G1, in each instance, is independently aryl or heteroaryl, wherein each G1 is independently unsubstituted O- with 1, 2, 3, 4 or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, -NO2 , -OR1b, -OC (O) R 1b, -OC (O) N (Rb) (R3b), -SR1b, -S (O) R2b, -S (O) 2R2b, -S (O) 2N (Rb) (R3b), -C (O) R 1b, -C (O) OR1b, -C (O) N (Rb) (R 3b), -N (Rb) (R 3b), -N (Ra) C (O) R1b , -N (R) C (O) O (R 1b), -N (Ra) C (O) N (Rb) (R3b), - (CR4bR5b) m-NO2, -N (Rb) S (O) 2 (R2b), - (CR4bR5b) m-OR1b, -C (OH) [(CR4bR5b) m-R4b] 2, - (CR4bR5b) m-OC (O) R 1b, - (CR4bR5b) m-OC (O) N (Rb) (R3b), - (CR4bR5b) m-RO1B, - (CR4bR5b) mS (O) R2b, - (CR4bR5b) mS (O) 2R2b, - (CR4bR5b) mS (O) 2N (Rb) (R3b) , - (CR4bR5b) mC (O) R1b, - (CR4bR5b) mC (O) OR1b, - (CR4bR5b) mC (O) N (Rb) (R3b), - (CR4bR5b) mN (Rb) (R3b), - (CR4bR5b) mN (R) C (O) R1b, - (CR4bR5b) mN (R) C (O) O (R 1b) - (CR4bR5b) mN (R) C (O) N (Rb) (R3b), - (CR4bR5b) mN (Rb) S (O) 2 (R2b), cyanoalkyl, and haloalkyl.Un compuesto de fórmula (I):**Fórmula** o una sal farmacéuticamente aceptable del mismo,donde A está seleccionado entre el grupo que consiste en R1, R3, R4, y R5 están seleccionados independientemente entre el grupo que consiste en hidrógeno, alquenilo, alquilo, haloalquilo, G1, G2, -(CR4aR5a)m-G1, y -(CR4aR5a)m-G2 R4a y R5a, en cada caso, cada uno es independientemente hidrógeno, halógeno, alquilo, o haloalquilo G1, en cada caso, es independientemente arilo o heteroarilo, donde cada G1 está independientemente sin sustituir osustituido con 1, 2, 3, 4 o 5 sustituyentes seleccionados entre el grupo que consiste
