A system for non-invasively elevating the temperature of tissue by ultrasound energy waves comprising at least one ultrasound delivery device adapted to deliver ultrasound energy waves to a focal point of targeted tissue, a temperature monitoring device for monitoring the temperature of targeted tissue, and a controller for steering and controlling the ultrasound delivery device to deliver ultrasound energy waves at a focal point less than about 15 mm3 and intensity of focus of the ultrasound energy waves in the range of about 500 W/cm' to about 3000 W/cm' to elevate the temperature of targeted tissue to a desired temperature.