<;p>;The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.<;/p>;<;p>;La presente invencion proporciona nuevos polipeptidos resistentes a la proteasa, asi como composiciones y metodos para tratar, mejorar o prevenir condiciones relacionadas con dano articular, incluyendo lesion aguda de articulaciones y artritis.<;/p>;