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DIRECT DRUG DELIVERY SYSTEM BASED ON THERMALLY RESPONSIVE BIOPOLYMERS
专利权人:
Duke University
发明人:
Lori A. Setton,Ashutosh Chilkoti,Virginia B. Kraus,Helawe Betre,Matthew R. Dreher
申请号:
US14297531
公开号:
US20140364371A1
申请日:
2014.06.05
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the composition comprising the compound of interest to be delivered (such as an antiinflammatory agent or a chemotherapeutic agent) and a polymer (such as an elastin-like peptide or ELP) that undergoes an inverse temperature phase transition, so that a sustained release of the compound of interest at the selected region is provided. Compositions useful for carrying out the invention are also described.
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