Diamidine derivatives of formula (I) and their salts are new. Amidine derivatives of formula (I) and their salts are new. [Image] X : a group of formula (ii) or R 4； Z : -(CH 2) m-； m : 8 - 21； n : 0 or 1； Y : R 3 or a group of formula (iii)； R 1 and R' 1H, alkyl, aryl, OH, O-alkyl, O-aryl, OCO-alkyl, OCO-aryl, O-CO-O-(or S or NH)-alkyl, O-CO-O-(or S or NH)-aryl, PO-(O-alkyl or O-aryl) 2, CO-O-CH 2-aryl, or cycloalkyl； R 2 and R' 2H, alkyl, CO-O-CH 2-aryl, CO-O-alkyl, or cycloalkyl； R 3 and R' 3H, alkyl, aryl, CO-O-alkyl, CO-O-aryl, COO-CH(R)-O-CO-alkyl, PO(O-alkyl, or O-aryl, or ONa) 2, or CO-O-CH(R)-aryl； R : H or alkyl； NR 1R 2, NR' 1R' 2, NR 2R 3, NR' 2R' 3a heterocycle, in which R 2 and R 3 and/or R' 2 and R' 3 may be doubly bonded to the nitrogen atom； R 4 and R' 4H or alkyl； R 1R 4, R' 1R' 4-(CH 2) p-； R 4R 2, R' 4R' 2-(CH 2) p； p : 3 - 5； and provided that: (1) when X is a group of formula (ii), then Y is R 3； and (2) when X is R 4, then Y is a group of formula (iii). [Image] Independent claims are also included for the preparation of compounds of formulae (V), (X), (VI) and (VIII). [Image] R anot defined. ACTIVITY : Protozoacide. 1,12-bis(imidazolin-2-yl) dodecane (Ib) was given orally and intraperitoneally to mice infected with Plasmodium vinckei. The dose that cleared 50 % of the infection (ED50) was 3.4 mg/kg i.p and 62 mg/kg p.o. MECHANISM OF ACTION : Not given in source material.本發明係關於具有抗寄生蟲活性之化合物，特別係抗瘧疾活性，其特徵在於其符合通式(I)；(I)；其中；-或者，X係代表式(II)之基團；(II)；其中Z係基團-(CH2)m，其中m=8至21，n=0或1，；且Y=R3，；.R1及R'1係彼此相同或不同，選自H、烷基、芳基、OH、O-烷基、O-芳基、O-CO-烷基、O-CO-芳基、O-CO-O(或S或NH)-烷基、O-CO-O(或S或NH)-芳基、PO(O-烷基或O-芳基)2、CO-O-CH2-芳基、環烷基，.R2及R'2係彼此相同或不同，選自H、烷基、CO-O-CH2-芳基、CO-O-烷基、環烷基，.R3及R'3係彼此相同或不同，代表H、烷基、芳基、CO-O-烷基、CO-O-芳基、COO-CH(R)-O-CO-烷基、PO(O-烷基或O-芳；基或ONa)2、CO-O-CH(R)-芳基，.R係H或烷基，或者，.R1及R2及/或R'1及R'2或是R2及R3及/或R'2及R'3與其所分別連結之氮原子共同形成一雜環，又或者，.R2及R3及/或R'2及R'3可為相同之取代基，雙連結於該氮原子上，分別與R1及R'1環化以形成雜環，該雜環如需要可經Ra取代，該Ra係選自H、烷基、經1、2、或3個鹵原子取代之烷基、芳基、CO-O-烷基(或芳基)、-CO-OH、-CO-NH2、-CN、-CO-NH-烷基(或芳基)、-CO-N
