SANDEEP DUTTA,DANIEL E. COHEN,THOMAS J. PODSADECKI,SCOTT C. BRUN,WALID M. AWNI,EMILY O. DUMAS,CHERI E. KLEIN,RAJEEV M. MENON,AMIT KHATRI,BARRY M. BERNSTEIN,SVEN MENSING
申请号：
ARP120103919
公开号：
AR088408A1
申请日:
2012.10.19
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Therapies without interferon and Ribavirin for the treatment of HCV. Preferably, the treatment is of a shorter duration, as no more than 12 Weeks. In One aspect, the Therapies include Managing at least two Direct acting antiviral agents without interferon and Ribavirin without a Guy With a hcv infection.For example, Therapies include administering to a subject a Therapeutic effective amount of a Therapeutic Agent (1, 2 or 3 a Therapeutic Agent and a cytochrome P450 inhibitor (EG, ritonavir).Claim 2: the method of claim 1, wherein said at least two DAAS comprising: a compound 1 or a pharmaceutically acceptable Salt thereof, and a compound 4 or a pharmaceutically acceptable Salt thereof, wherein the compound 1 or the Salt thereof is co admin Istra with ritonavir.Claim 10: the method of claim 1, wherein said at least two DAAS include PSI bags-7977 and TMC - 435. Claim 14: Method of claim 1, wherein said at least two DAAS include PSI bags-7977 and daclatasvir. Claim 18: the method of claim 1, wherein said at least two DAAS include PSI bags-7977 and gs-5885.Claim 22: the method of claim 1, wherein said at least two - and 790052 DAAS include BMS BMS - 650032, and such treatment lasts for 10, 11 or 12 Weeks. Claim 28: the method of claim 1, wherein said at least two include DAAS and daclatasvir INX - 189.Terapias sin interferón y sin ribavirina para el tratamiento de HCV. Preferiblemente, el tratamiento es de una duración más breve, tal como no más de 12 semanas. En un aspecto, las terapias comprenden administrar al menos dos agentes antivirales de acción directa sin interferón y sin ribavirina a un sujeto con una infección por HCV. Por ejemplo, las terapias comprenden administrar a un sujeto cantidades eficaces de un agente terapéutico 1, un agente terapéutico 2 (o un agente terapéutico 3) y un inhibidor de la citocromo P450 (por ejemplo, ritonavir). Reivindicación 2: El método de la reivindicación 1, caracterizado porque dichos al menos dos DAAs comprenden: un compuesto
