Method for treating an inflammatory disease by administering a 1,2,3,4- tetrahydroquinoxaline compound containing a phenyl group having a sulfonic acid ester structure introduced therein as a substituent
Masatomo Kato,Miwa Takai,Takahiro Matsuyama,Tatsuji Kurose,Yumi Hagiwara,Kenji Oki,Mamoru Matsuda,Toshiyuki Mori
申请号：
US13063186
公开号：
US08664221B2
申请日:
2009.09.11
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The object aims to find a novel pharmacological activity of a novel 1,2,3,4-tetrahydroquinoxaline derivative which contains, as a substituent, a phenyl group having a sulfonic acid ester structure introduced therein. A compound represented by general formula (1) or a salt thereof is useful as a glucocorticoid receptor agonist, particularly as a therapeutic agent for diseases against which a glucocorticoid receptor agonist (e.g., a steroid) is believed to be effective, such as inflammatory bone/joint diseases, inflammatory ophthalmic diseases (inflammatory ophthalmic diseases in the anterior or posterior segment of an eye). R1 represents a group represented by general formula (2a), (3a), (4a) or (5a)； R2 represents a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, or the like； R3 represents a lower alkyl group； R4, R5, R6 or R7 represent a halogen atom, a lower alkyl group which may have a substituent, a hydroxy group, a lower alkoxy group which may have a substituent, or the like； and m, n, p or q represents a number of 0, 1 or 2.
