PROBLEM TO BE SOLVED: To provide an endoscope system, an endoscope processor device, and an operation method of the endoscope system capable of improving visibility of blood vessels at a target depth and having target thickness, and identifying each blood vessel from other blood vessels having other depth and thickness.SOLUTION: An endoscope system 10 comprises: a V-LED 20a for emitting V-light having a depth resolution with respect to blood vessels a G-LED 20c for emitting G-light having a thickness resolution with respect to blood vessels and a blood vessel image generation part 63 for, using a first image signal corresponding to the V-light, and a second image signal corresponding to the G-light, for generating a blood vessel image which displays the blood vessels having a target depth and target thickness.SELECTED DRAWING: Figure 2COPYRIGHT: (C)2016,JPO&INPIT