A lip-care lipstick with antibacterial, anti-inflammatory and anti-oxidation effects relates to the technical field of daily necessities. The present invention aims to provide a lip-care lipstick with antibacterial, anti-inflammatory and anti-oxidation effects. The lip-care lipstick contains a Manuka honey active ingredient ME lip-care factor and plant medicinal extracts, which can repair and prevent the cracking and peeling of lips, promote the metabolism of tender skin, inhibit the inflammation of the lips and care the lip skin. The lip-care lipstick has a significant effect on the treatment of cheilitis. The lip-care lipstick includes the following components in parts by weight: 15-30 parts of Manuka honey containing the ME lip-care factor, 0.1-1 part of dipropylene glycol, 0.5-1.5 parts of allantoin, 47-50 parts of emollient, 3-15 parts of plant essential oil, 0.15-6.5 parts of colorant, 6 parts of thickener, 5 parts of binder and 6 parts of antioxidant.