您的位置: 首页 > 农业专利 > 详情页

DIAGNOSIS AND TREATMENT OF A MALIGNANT TUMOR USING ANTIBODY AGAINST EREG
专利权人:
ДЗЕ ЮНИВЕРСИТИ ОФ ТОКИО (JP);ЧУГАИ СЕЙЯКУ КАБУСИКИ КАЙСЯ (JP)
发明人:
АБУРАТАНИ Хироюки (JP),ИТО Хиротака (JP),ЙОСИДА Кендзи (JP)
申请号:
RU2014141151
公开号:
RU2014141151A
申请日:
2014.10.13
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An anti-cancer agent, comprising as an active ingredient an antibody that binds to an EREG protein, wherein said antibody has ADCC activity, CDC activity and / or neutralizing activity against an EREG protein, where antibody (i) binds to the same epitope of an EREG protein that the antibody according to any one of subparagraphs (1) to (43) below, and (ii) is not the same antibody as described in subparagraphs (1) to (43) below: (1) an antibody containing H chain having the amino acid sequence of SEQ ID NO: 2 in to as CDR1, the amino acid sequence of SEQ ID NO: 4 as CDR2 and the amino acid sequence of SEQ ID NO: 6 as CDR3, and containing the L chain having the amino acid sequence of SEQ ID NO: 12 as CDR1, the amino acid sequence of SEQ ID NO: 14 as CDR2 and the amino acid sequence of SEQ ID NO: 16 as CDR3; (2) the antibody according to (1), where the H chain has the amino acid sequence from positions 117-452 in the amino acid sequence of SEQ ID NO: 8 as CH; (3 ) the antibody according to (1), where the H chain has an amino acid sequence the identity from positions 117-446 in the amino acid sequence of SEQ ID NO: 10 as CH; (4) the antibody according to (1), where the L chain has the amino acid sequence from positions 107-213 in the amino acid sequence of SEQ ID NO: 18 as CL ; (5) the antibody according to (1), where the L chain has the amino acid sequence from positions 107-213 in the amino acid sequence of SEQ ID NO: 20 as CL; (6) the antibody containing the H chain according to (2) and the L chain according to (4); (7) an antibody containing an H chain according to (3) and an L chain according to (5); (8) an antibody containing an H chain having ami the acid sequence of SEQ ID NO: 49 as CDR1, the amino acid sequence of SEQ ID NO: 51 as CDR2 and the amino acid sequence of SEQ ID1. Средство против злокачественной опухоли, содержащее в качестве активного ингредиента антитело, которое связывается с белком EREG, где указанное антитело обладает ADCC активностью, CDC ак
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
相关发明人
相关专利

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充