A fine needle aspiration device with a modified handle and cannula through which a vacuum is delivered to the targeted tissue for removal of liquid or cellular samples is provided, the vacuum being provided via a flexible tubing capable of fitting within a restricted space such as, for example, a CT gantry. A vacuum source may be provided to assist the fine needle aspiration procedure via flexible tubing, which allows the vacuum source to be located outside the CT gantry or on the patient.