Embodiments of the invention concern the regeneration of chondrocytes and cartilage type cells. In certain embodiments one or more genes are employed for the regeneration of chondrocytes and ca1iilage type cells. In particular embodiments one or more gene therapy regimens are employed for the regeneration of chondrocytes and cartilage type cells. In particular aspects embodiments concern cartilage repair such as articular cartilage repair. More particularly embodiments for the disclosure concern using gene therapy for the attraction generation and/or regeneration of chondrocytes or other cartilage type cells and/or the generation and/or repair of cartilage tissue. In specific embodiments of the disclosure gene therapy is provided that is capable of attracting and/or generating desired cells in vivo.
