PROBLEM TO BE SOLVED: To provide a synthetic biomaterial including polymeric hydrogels.SOLUTION: The method for manufacturing the biomaterial includes a step of combining two or more precursor components of the biomaterial under conditions that allow polymerization of the two components, where polymerization occurs through self selective reaction between a strong nucleophile and a conjugated unsaturated bond or a conjugated unsaturated group, by nucleophilic addition. The functionality of each component is at least two, and the biomaterial does not comprise unprocessed albumin. In addition, the conjugated unsaturated bond or group is not a maleimide or a vinyl sulfone.COPYRIGHT: (C)2012,JPO&INPIT【課題】重合性ヒドロゲルを含む合成生体適合材料の提供。【解決手段】生体適合材料を作製するための方法であって、2つの組成物の重合が可能となる条件下で該生体適合材料の2つまたはそれ以上の前駆組成物を化合させる段階を含み、求核付加による強い求核試薬と共役不飽和結合または共役不飽和基との間の自己選択的反応によって該重合が生じ、各組成物の官能価(functionality)が少なくとも2であり、該生体適合材料が、処理されていない(unprocessed)アルブミンを含まず、該共役不飽和結合または共役不飽和基がマレイミドまたはビニルスルホンではない方法。【選択図】なし