Production method or continual production method of the oral administration medicine where the medicine is done to be enclosed is offered to the connotation section which was formed by the fact that as for this invention, first water swelling gel cambium and second water swelling gel cambium is provided in outermost layer, the margin of first and second water swelling gel cambium directly or through adhesive layer, is connected. This production method or continual production method has the process below. (A) the process which forms first water swelling gel cambium, (b) the process which forms the concave section in the specified part of first water swelling gel cambium, (c) the process which fills up the medicine on the concave circles which were formed, and, (d) on the medicine which fills up, directly or through adhesive layer, the process which forms second water swelling gel cambium, connects the margin of the concave section.本発明は、第一の水膨潤性ゲル形成層及び第二の水膨潤性ゲル形成層が最外層に設けられ、第一と第二の水膨潤性ゲル形成層の周縁部どうしが直接又は接着剤層を介して接合されることにより形成された内包部に、薬物が封入されされた経口投与剤の製造方法、又は連続製造方法を提供する。この製造方法又は連続製造方法は、以下の工程を有する。(a)第一の水膨潤性ゲル形成層を形成する工程、(b)第一の水膨潤性ゲル形成層の所定部分に凹部を形成する工程、(c)形成した凹部内に薬物を充填する工程、及び、(d)充填された薬物の上に、直接又は接着剤層を介して、第二の水膨潤性ゲル形成層を形成し、凹部の周縁部を接合する工程。
