Medical systems, devices and methods are provided for accessing a bodily openingthat, among other things, are safe, reliable and repeatable. A medical systemfor accessing a bodily opening generally includes a medical instrument and anovertube. The overtube defines an overtube lumen that is sized to receive themedical instrument. The overtube includes a distal end having a tapered portionand a plurality of longitudinally extending slits defining a plurality of flaps.The tapered portion of the overtube is sized relative to the medical instrumentsuch that translation of the medical instrument through the distal end of theovertube forces the plurality of flaps to move radially outwardly.