PROBLEM TO BE SOLVED: To provide a liquid sustained-release suspension dosage form comprising an ionized form of water-soluble drugs.SOLUTION: There is provided a liquid-form controlled-release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix. The surface charge of the ion-exchange matrix is opposite to that of the electrolytic drug. The dispersed phase further comprises a non-electrolytic soluble component having a low molecular weight, a diffusion controlling membrane and a dispersion medium substantially free of diffusible counter ions, and further comprises an excipient capable of associating with water and impeding water activity. Accordingly, drug dissolution is inhibited prior to administration. There are also provided a method for preparation of the composition and a treating method.COPYRIGHT: (C)2013,JPO&INPIT【課題】水溶性薬物のイオン化された型を含有する液体徐放性懸濁液剤形の提供。【解決手段】医薬として許容し得るイオン交換マトリックス及び該イオン交換マトリックスに会合された水溶性電解質薬物を含有するイオン交換マトリックス薬物複合体を含む分散相を含有する液体型放出制御薬剤組成物。該イオン交換マトリックスの表面電荷は、電解質薬物の表面電荷とは反対である。該分散相は更に、低分子量を有する非電解質の可溶性成分、並びに拡散制御膜及び実質的に拡散性対イオンを含まない分散媒を含有し、更に水と会合し水活性を妨げることが可能である賦形剤を含有する。その結果薬物溶解は投与前に阻害される。更に当該組成物の調製法及び治療法も示す。【選択図】図1
