The present invention relates to a herbal composition to treat gastrointestinal inflammatory diseases in a subject suffering therefrom. The present invention further provides a method to use a pharmaceutical effective amount of the herbal composition to treat Gl inflammatory diseases. Particularly, this invention relates to using a pharmaceutically effective amount of the herbal composition extract having the ability to inhibit the expression of pro-inflammatory cytokines, attenuate disruption of epithelial barrier, and modulate gut function
