Indole derivatives (I), are new. Indole derivatives of formula (I) and their salts are new. R a, R bH, halo, 1-6C alkyl, CF 3, CN, COR 2, OR 2 or phenyl (optionally substituted by 1-4C alkyl or CF 3)； R 21-4C alkyl, CF 3 or phenyl (optionally substituted by 1-4C alkyl or CF 3)； R 2H or 1-4C alkyl； R : H or 1-3C alkyl； n : 1-3； X : a bond or O, and Ar 1phenyl, naphthyl, quinolinyl, isoquinolinyl, pyridinyl, pyrazolyl, imidazolyl, isoxazolyl, thiazolyl, benzothiazolyl, 2,1,3-benzothiadiazolyl, 3,4-dihydro-1,4-benzoxazinyl, 5,6,7,8-tetrahydronaphthlaneyl, 1,2,3,4-tetrahydroquinolinyl, 1,2,3,4-tetrahydroisoquinolinyl, 1,2,3,4-tetrahydro-2-oxoquinolinyl, 3,4-dihydro-2H-benzopyranyl, indolyl, 2,3-dihydroindolyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxanyl or benzoxazolyl (all optionally substituted by halo, 1-6C alkyl, CF 3, CN, CO-R 2, OR 2, NH-COR 2, morpholinyl, amino or 4-morpholinosulfonyl). Independent claims are included for the preparation of (I). [Image] ACTIVITY : Antilipemic； Antidiabetic； Cardiovascular-Gen.； Antiinflammatory； Neuroprotective； Nootropic； Antiparkinsonian； Anorectic； Antiarteriosclerotic； Cardiant； Hypotensive； Antiarthritic； Antirheumatic. MECHANISM OF ACTION : Peroxisome proliferator activated receptor (PPAR) activator. In a test used to determine activation of PPAR-alpha and/or PPAR-gamma , results showed that (I) exhibited an EC 50 value of 50 nM.본 발명은 청구항에 정의된 것과 같이 일반 구조식(I):(I)의 인돌로부터 유래된 화합물 및 이들의 약학적으로 허용가능한 부가염에 관한 것이다.본 발명은 또한 상기 화합물의 제조공정, 이들이 포함되는 약학적 조성물, 및 특히, 고트리글리세라이드증, 고지질증, 고콜레스테롤증, 당뇨병, 내피의 기능이상, 심혈관 질환, 염증성 질환 및 신경퇴행성 질환의 치료에 있어서 약학적으로 활성인 기질로서의 이들의 용도에 관한 것이다.
