Ralph Leon BIEMANS,Dominique BOUTRIAU,Philippe DENOEL,Pierre DUVIVIER,Carine GORAJ
申请号：
US15529094
公开号：
US20170281744A1
申请日:
2015.12.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The application discloses a method of immunising against Staphylococcus aureus infection comprising a step of administering to a human patient a single dose of an immunogenic composition comprising； (i) a Staphylococcus aureus ClfA protein or immunogenic fragment thereof at a dose of 5-50, 10-30, 5-15 or 20-40 μg and (ii) a pharmaceutically acceptable excipient； wherein the pH of the composition is pH 5.0-pH 8.0. The application further discloses an immunogenic composition comprising； (i) a S. aureus Type 5 capsular saccharide conjugated to a carrier protein, (ii) a S. aureus Type 8 capsular saccharide conjugated to a carrier protein, (iii) a ClfA protein or immunogenic fragment thereof, (iv) an alpha toxoid, and (v) a pharmaceutically acceptable excipient； wherein the pH of the immunogenic composition is pH 5.0-pH 8.0
