Lewis, Jason G.,Leadbetter, Michael Robert,Caldwell, Jeremy,Dragoli, Dean,Bell, Noah,Jacobs, Jeffrey W.,Finn, Patricia,Jain, Rakesh,Chen, Tao,Siegel, Matthew
申请号：
AU2016369631
公开号：
AU2016369631A1
申请日:
2016.12.19
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: (I'), where R
