Thiazole compounds and their use for inhibiting phosphodiesterase 4, TNF-α, and IL-4

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专利权人:

Isao Takemura;Yoko Sakamoto;Hidetaka Hiyama;Kenji Watanabe;Kunio Oshima;Nobuaki Ito;Takumi Sumida;Hideki Kitagaki;Hideki Kawasome;Hironobu Ishiyama;Masatoshi Chihiro;Kazuhiko Fujita;Junpei Haruta

发明人:

Isao Takemura,Kenji Watanabe,Kunio Oshima,Nobuaki Ito,Junpei Haruta,Hidetaka Hiyama,Masatoshi Chihiro,Hideki Kawasome,Yoko Sakamoto,Hironobu Ishiyama,Takumi Sumida,Kazuhiko Fujita,Hideki Kitagaki

申请号：

US12638143

公开号：

US08450352B2

申请日:

2009.12.15

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Thiazole compounds for inhibiting the activity of phosphodiesterase 4, the production of tumor necrosis factor alpha, and the production of interleukin 4. The compounds of the invention are represented by general formula (1):wherein A is any one of the following groups (i)-(iii): (i) —CH(OH)—B— wherein B is a C1-6 alkylene group； (ii) —COCH(COOR3)-Bb- wherein R3 is a C1-6 alkyl group and Bb is a C1-6 alkylene group； and (iii) -Bc- wherein Bc is a C2-6 alkylene group, and include optical isomers and salts of the compounds.

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