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METHOD FOR PRODUCING INHALATION POWDERS
专利权人:
КЛИНИПРО КО.; ЛТД. (JP)
发明人:
ОНО Шиничи (JP)
申请号:
RU2013154972/15
公开号:
RU2013154972A
申请日:
2013.02.25
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of manufacturing powders for inhalation, comprising: a first mixing step, comprising mixing the first active component and the carrier in the presence of a grinding medium, and mixing the first active component and the carrier while grinding the agglomerates of the first active component in order to obtain a mixture of the carrier and the first active component; and a second mixing step, including adding finely divided powders to the mixture obtained in the first mixing step, and mixing and mixing the mixture and finely divided powders in the presence of a grinding medium. 2. A method for manufacturing inhalation powders according to claim 1, characterized in that in the first mixing step a second active component is added that is different from the first active component. A method of manufacturing inhalation powders according to claim 1, characterized in that in the second mixing step a second active component is added that is different from the first active component. A method of manufacturing powders for inhalation according to claim 2 or 3, characterized in that the first active component has higher cohesive properties compared to the second active component. A method of manufacturing powders for inhalation according to claim 2 or 3, characterized in that the first active component is salmeterol xinafoate, and the second active component is fluticasone propionate. A method of manufacturing powders for inhalation according to claim 1, characterized in that the average particle diameter of the fine powders is from 1/50 or more to 1/5 or less for the average particle diameter of the carrier. A method of manufacturing powders for inhalation according to claim 6, characterized in that each1. Способ изготовления порошков для ингаляции, включающий:первый этап смешивания, включающий перемешивание первого активного компонента и носителя в присутствии среды размола, и смешивание первого активного компонента и носителя при одновременном измельчении агломератов
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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