Restrictive inverted terminal repeats for viral vectors

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专利权人:

Curtis Hewitt

发明人:

Curtis Hewitt,Richard Jude Samulski

申请号：

US13521448

公开号：

US09169494B2

申请日:

2011.01.12

申请国别(地区):

US

年份:

2015

代理人:

摘要：

This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors.

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中国工程科技知识中心

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http://www.ckcest.cn/home/