Described herein are anti-SIRPα antibodies, polynucleotides encoding anti-SIRPα antibodies, host cells containing such polynucleotides, methods of making and using such anti-SIRPα antibodies or polynucleotides, pharmaceutical compositions containing such anti-SIRPα antibodies or polynucleotides, as well as mixtures or bispecific antibodies comprising such anti-SIRPα antibodies or polynucleotides encoding such mixtures or bispecific antibodies.L'invention concerne des anticorps anti-SIRPα, des polynucléotides codant pour des anticorps anti-SIRPα, des cellules hôtes contenant de tels polynucléotides, des procédés de fabrication et d'utilisation de tels anticorps ou polynucléotides anti-SIRPα, des compositions pharmaceutiques contenant de tels anticorps anti-SIRPα ou des polynucléotides, ainsi que des mélanges ou des anticorps bispécifiques comprenant de tels anticorps anti-SIRPα ou des polynucléotides codant pour de tels mélanges ou anticorps bispécifiques.