The present invention belongs to the field of titanium alloy materials, and disclosed are a high-strength and low-modulus β-type Si-containing titanium alloy, a preparation method therefor and the use thereof. The preparation method involves: preparing an alloy component with, in atomic percentage, 60-70% of Ti, 10-20% of Nb, 5-15% of Zr, 1-10% of Ta and 1-5% of Si and using sponge titanium, sponge zirconium, a tantalum-niobium intermediate alloy and silicon as raw materials, and then uniformly smelting the alloy component to obtain a solidified ingot; then, subjecting the resulting ingot to high temperature plastic deformation with a deformation temperature of 800-900° C. and a deformation rate of 60-80%, and water-quenching same to room temperature; and finally, heating the resulting test sample to a recrystallization temperature, maintaining the temperature for 1-4 h, and carrying out an annealing treatment and air-cooling same to room temperature to obtain the high-strength and low-modulus β-type Si-containing titanium alloy. The resulting titanium alloy has a higher strength, a greater plasticity, a lower elastic modulus and a finer grain size, and is more suitable for use as a medical implant material.