Particular members of the multisubunit immune recognition receptor (MIRR)family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell receptor (pro-BCR), Ig Fc receptors(FcR), and NK receptors, can be physically uncoupled from their associatedtransducers. The invention describes regulatory compounds and methods formimicking such dissociation/destabilization for the purposes of receptordesensitization and for treatment of conditions in which receptordesensitization or alternatively, enhanced or prolonged receptorsensitization, is desirable. Compounds and methods for enhancing or prolongingreceptor sensitization are also disclosed, as are methods for identifyingregulatory compounds suitable for use in the present methods.
