The present invention relates to an adipose-derived mesenchymal stem cell (ASC) which over-expresses Granulocyte chemotactic protein-2 (GCP-2). According to the present invention, the ASC over-expresses VEGF-A and HGF genes, promotes generation of blood vessels, and reduces a left ventricular end diastolic diameter (LVEDD) and a left ventricular end systolic diameter (LVESD). The ASC enhances a heart function by increasing a left ventricular ejection fraction (LVEF), and increase vascular density of an ischemic area. Therefore, the ASC can be advantageously used for treating ischemic diseases.COPYRIGHT KIPO 2015본 발명은 GCP-2(Granulocyte chemotactic protein-2) 유전자를 과발현하는 지방 간엽줄기세포(adipose-derived mesenchymal stem cells, ASCs)에 관한 것이다.본 발명에 따른 지방 간엽줄기세포는 VEGF-A 및 HGF 유전자를 과발현하여 혈관형성을 촉진하고, LVEDD(left ventricular end diastolic diameter) 및 LVESD(Left ventricular end systolic diameter) 값을 감소시키며, LVEF(Left ventricular ejection fraction) 값을 증가시켜 심장기능을 개선시키고, 허혈성 부위(ischemic area)의 혈관 밀집도(vascular density)를 증가시켜, 허혈성 질환의 치료에 유용하게 사용될 수 있다.
