Michael D. BUSCHMANN,Marc LAVERTU,Monica NELEA,Vincent DARRAS,Mohamad Gabriel ALAMEH,Anik CHEVRIER,Nicolas TRAN-KHANH,Ashkan NAEINI TAVAKOLI,Daniel VEILLEUX
申请号：
US15549971
公开号：
US20180028458A1
申请日:
2016.02.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure relates to a nucleic acid delivery composition comprising a coated chitosan-based polyplex, wherein the coated chitosan-based polyplex comprises: a chitosan an isolated nucleic acid and an additional polyelectrolyte. The coated chitosan-based polyplex has an initial or a final molar ratio of amine groups of chitosan (N) to phosphate groups of the nucleic acid (P) to carboxyl groups of the additional polyelectrolyte (C) (N:P:C), wherein the N has a value between about 1.0 and about 10.5, the P has a value between about 1.0 and about 2.0 and the C has a value between about 1.0 and 10.5.
