PROBLEM TO BE SOLVED: To provide such a pharmaceutical composition for use in ophthalmic agents (eyewash, eye-drop, etc.) as has an excellent improvement effect on the eyestrain, especially as is also excellent in immediate effectiveness.SOLUTION: This pharmaceutical composition includes vitamin B12 and berberine and/or a salt thereof, wherein the pharmaceutical composition has a viscosity at 25°C of 1-60 cp.COPYRIGHT: (C)2012,JPO&INPIT【課題】優れた眼精疲労改善効果を有し、特に即効性にも優れている眼科用剤(洗眼薬、点眼薬など)などの医薬用組成物を提供する。【解決手段】ビタミンB12と、ベルベリン及び/又はその塩とを含有することを特徴とする医薬用組成物。【選択図】なし