Implantable sensor and associated receiver apparatus, and methods of manufacturing, implantation, and use. In one embodiment, the sensor apparatus is a heterogeneous glucose sensor, including hydrogen peroxide-based detector elements and oxygen-based detector elements. The sensor apparatus utilizes one (type) of the detector elements to confirm the accuracy of, and/or calibrate, the second (type of) detector element, so as to among other things enable the second type of detector to operate more robustly, and/or for a longer period without external calibration and/or explants. In one variant, the heterogeneous detector types are contained within a common biocompatible implantable housing. In another variant, the first type of detector (e.g., oxygen based) is disposed within a separable module that can operate independently of (or mechanically and/or electrically interface with) the second type of detector. In yet another variant, an external receiver compatible with both the first and second types is disclosed.
